Tosoh offers the advanced G7 HPLC Analyzer for β-thalassemia testing


The term thalassemia is used to describe globin gene disorders that result from a diminished rate of synthesis of one or more globin chains.  This in turn causes a reduced rate of synthesis of the hemoglobin or hemoglobins of which that chain constitutes a part.  Alpha thalassemia indicates a reduced rate of synthesis of the α globin chain.  Similarly, β, δ, δβ and εγδβ thalassemias indicate a reduced rate of synthesis of the individual chains. Thalassemia is the most common single gene disorder known.

Thalassemia may be suspected if an individual shows signs that are suggestive of the disease. However, in all cases, laboratory diagnosis is essential to confirm the exact diagnosis and to allow for the provision of exact genetic counselling about recurrence risks and testing options for parents and affected individuals.

Likewise, screening is recommended to determine trait status for individuals of high risk ethnic groups.


The β-thalassemias are a group of conditions resulting from a reduced rate of synthesis of the β globin chain. More than 200 β gene mutations have been identified, occurring in a wide range of ethnic groups, and within each geographic population there are unique mutations.

β thalassemia mutations are divided into two broad categories, β0  (β-zero) thalassemia and β+ (β-plus) thalassemia. In β0 thalassemia there is either an abnormal gene that is not expressed or, less often, gene deletion. In β+ thalassemia there is reduced, but not absent, expression of the abnormal gene so that even in the homozygous state there is still some hemoglobin A production. 

Tosoh G7 HPLC Analyzer »

Tosoh G7 has both HbA1c and β-thalassemia programs to provide full patient profile.

System Features:
• HbA1c and β-thalassemia in one analyzer
• HbA1c results in 2.2 minutes
• NGSP certified
• Direct determination of stable HbA1c

Switching Modes:
Switching between the HbA1c and β-thalassemia programs is simple and fast. Just remove the HbA1c reagents, replace them with the β-thalassemia reagents, and let the instrument do the rest. Once the buffers and column have been changed, the system is automatically primed and is ready to perform analysis within minutes.

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