Immunoassay Testing Post

Vitamin D Product Focus: Don’t Underestimate Vitamin D

 25-OH Vitamin D is a challenging analyte to accurately measure in human blood due to presence of 25-OH Vitamin D2, Vitamin D binding proteins and Vitamin D metabolites. Variability between different methods due to lack of standardization has added to the challenges.
The Endocrine Society recommends 30 - 100 ng/mL as optimal levels of total 25-OH Vitamin D. Therefore it is essential that immunoassays have equimolar affinity for 25-OH Vitamin D3 and D3 to align with this reference range.
External quality assurance programs, such as DEQAS and various publications have demonstrated that many immunoassays underestimate 25-OH Vitamin D because they do not measure 25-OH Vitamin D2 and D3 in an equimolar fashion.
The Tosoh ST AIA-PACK 25-OH Vitamin D assay correlates well with gold standard methods and measures equimolar concentrations of 25-OH Vitamin D2 and D3. The assay aligns well with the clinical state and the recommendations of the Endocrine Society and National Kidney Foundation.

For more detailed information please contact Market Development Manager, Shanti Narayanan at [email protected]

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